No. 1 Chicago, Ill.
With 7.3% unemployment and a gallon of gas going for just under four bucks, the Windy City has some economic headwinds that result in a perfect storm for stress. Chi-town’s pollution problems (it ranked No. 7 in terms poor air quality) and lack of breathing room (it's No. 2 in terms of population density) couple to create a Midwestern Molotov cocktail of stress.
Explains alot about my mood lately...